منابع مشابه
Bugs on Drugs Go GAGAA
Replacement of C-H in pyrrole with N: in imidazole allows for the formation of a hydrogen bond with this Seattle, Washington 98109 guanidine NH 2. In the context of a side-by-side dimer, a G/C base pair is contacted by an imidazole (Im) touching guanine and a pyrrole (Py) touching cytosine. For exam-Sometimes science fact resembles science fantasy, ple, GTA/CAT can be recognized by ImPyPy/PyPyP...
متن کاملDesigner drugs and sexual dysfunction
New or novel psychoactive substances (NPS) are the most recent forms of designer drugs. These materials are sold as “bath salt” mixtures or fertilizers through the internet and in head shops worldwide [1]. Of course there are no proven medical purpose of these compounds which mostly contain synthetic cathiones or piperazines. The form is usually powder or bath salt like crystalline which are in...
متن کاملDesigner Drugs: A Synthetic Catastrophe
Synthetic stimulants can cause hallucinations, aggressive behaviors, death and are sometimes legal. These substances are sold as plant food and bath salts that are "Not for Human Consumption", therefore skirting the 1986 Federal Analogue Act and giving a false pretense of safety. Studies have proved that these substances are toxic, have a high abuse potential, and are becoming extremely prevale...
متن کاملDesigner bugs: structural engineering to build a better mouse model.
Many animal models of bacterial diseases are hampered by differences in tissue tropism and the course of pathogenesis. In a recent issue of Cell, by rationally mutating a surface invasion protein (InlA) to have higher binding affinity for its cognate host receptor (E-cadherin), Wollert et al. were able to "murinize"Listeria monocytogenes, creating a strain capable of invading intestinal epithel...
متن کاملAminoglycoside Resistance in ICUs: Are We Running out of Drugs, for Bad Bugs
Many classes of antibacterial drugs are currently available for physicians to use, however the plan of antibiotic development has slowed during the last decade. The World Health Organization (WHO) has identified antimicrobial resistance as one of the 3 most important problems for human health. Antimicrobial resistance is a growing problem worldwide, especially in hospitals, where resistant orga...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1012547107